Oh yes, definitely! I’m currently printing the parts for my machine. It uses V-slot and so can be scaled in size, including size of bed. I’m also experimenting with coupling wire to belt. CoreXY is the next logical step after a desktop printer.
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(have an original Rostock and also a Kossel delta 
If you need bigger XY motion than go for it, also the option to use a direct driver extruder can be benefit compared to a Delta(lower retraction amounts and to print flex materials).
A good corexy printer can handle almost the same acceleration settings that a delta printer so they can be as fast, but without the pain of calibration and their print resolution is the same across the whole build plate.
If you have a nicely calibrated Delta the print quality of the COREXY will not be better.
Hi ! I am interested to learn more about this subject too. I have a “Voron CoreXY” in my mind, but not ready to jump on the coreXY train yet.
In my design I’m using V-slot so my bed chassis rides up and down that on all four corners using elongated runners and has a leadscrew halfway along the left and right sides. I feel it’ll be rather stable.
I built a C-Bot as my very first printer with a 300mmx300mmx500mm build envelope. It uses V-Slot. The build thread can be found on openbuilds under Carl Feniak’s design It prints exceedingly well and my benchmark prints come out much better than most I see online.
I have linked this many times but who is willing to understand the different belt designs please read and understand this blog entry:
http://blog.fabtotum.com/blog/2014/04/04/belts-and-stuff-experiences-to-share/ 424
It has all the information and calculations.
It will make clear how the XY motion is handled.
The only thing you have to design is the Z axis and this where a lot of printers are suffer. It has to be as stable as possible, if you grab the front of the table and move it up and down or right to left it should not flex/move at all. As any possible play of the table will catch up resonance of the XY motion during print and will show up in the print.
If you want to build a stable buildplate use 2 lead screws on the sides of the table and 2 or 4 linear rails(for bigger tables) to support it.
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