For design I use Fusion 360 which is an Autodesk product.
For a slicer if you are getting the real MK2 then use Slic3r that Prusa is providing. They just released driver version 175 yesterday which includes needed drivers, and their modified version of slic3r plus Pronterface and some other stuff.
Yes, I have the original MK2 and they told me it will come wit Slic3r.
So I am mostly looking for design software. Fusion 360 subscription plan ($300 / year) is too high for me. Plus I don’t feel like adding another subscription to my life, I’d rather pay and get unlimited licence.
Prusa doesn’t support slic3r and have pulled it from their site. I use simplify3d to slice, and fusion for design. Simplify3d is the best slicer I’ve used so far. Best money I’ve spent. Will save you a ton of printing time. I tried to slice a model in cura estimated print time was 14+ hours. Same model in simplify3d about 6 hours.