Yes you can use Cura with a reprap. The Cura configuration allows you to select Prusa Iteration 3. I have an it2 but the settings are easy to adjust. I exported the sliced file to my c drive and use pronterface to load the sliced cura file to print it. You can directly print with Cura as well but my power supply does switch off when both heaterbed and extruder go full on. In pronterface i have the option to preheat the bed first and then swith on the extruder without tripping up my power supply, Cura does not (or I have not figured this out yet). Of course i could change my power supply for a sturdier type but so far it works for me. Cura is free and can be downloaded from their web site. Try it out and let me know what your experiences are. User Richrap has written some interesting articles about slicer and its settings like changing perimeter which has a hug impact on the print quality and performance. I have not grasped the extire article yet but will try out his experiment with printed gears and diffierent perimeter settings in slicer.
I’ve used Cura winc 14.1 and it’s pretty good. I do miss the manual temp controls of Pronterface. but all in all Cura prints really well. I have found another issure though that sometimes it makes a gcode that has gaps in it, or offsets. it’s just once in a while, but it is annoying. Mainly if they had the Temp controls easier to manage I’d be really happy. You can use pronterface with it, but it’s not as easy as with slicr. I do like how well it prints and the on the fly changes. oh, my Cura crashes out whenever I try to pause a print. It’d be nice if someone would write a nice resume function, such as manually control, lift from deck, to hight, then position at a point in the model and manually on your print, then hit go and it calibrates, then resumes from that set point in the G code. That would be awesome. to bad I suck at programming.
I use Cura for two+ years, and it is great for those who starting with 3D print. Simple and easy to use, but missing some features or optimized in the way to become quick. I would like to have option for various infills geometry. Current orthogonal infill is good for some but not for all prints. I use it with Ultimaker but also with RepRap’s, but also use other opensource software as well.