Those problem can happen in many situations.
1st reason is the material. Is it the first time you’re using PLA on the 2X?
If so, chances are your Rep 2X isn’t “ready” to print PLA. They used to say it prints both but out of the box it doesn’t. If that’s the case, I’ll let you know how you can overcome this problem.
Otherwise, it can be the common problem of the extruder.
One radical fix is to change it by a custom one made with ABS (Replicator 2X Extruder Drive Block Upgrade by rmcniff - Thingiverse 1). Once you do that, you can print any filament no matter what its quality is. Which brings to the 3rd issue.
The filament. If the quality is bad, the diameter musn’t be consistant so you can either change your profile (custom) after you used a caliper to know (on x and y axis of the filament to make sure it’s not oval) the size of the filament (real size vs theory).
It can happen with MB filaments too…
2. Every time that I have the faulty layers it is one of these two problems:
A) Specially ABS and the old Colorfabb (in black spool) leave residues which make a burnt crust inside the walls of the extruder. You need to clean it every 150 hours. I use this great and simple tool by Henry Thomas Nozzle cleaning tool by whpthomas - Thingiverse This has solved the problem every time.
You will begin to hear the clicking sound as the filament struggles to slide. The result is a series of spits instead of an even flow of filament. This is more apparent when extruding long lines.
B) Tangled filament. when you change spools be careful to put the tip of the filament trough one of the holes that you find at the edge of every spool. It is important to keep the filament tight in the spool because otherwise it gets tangled, every time that the extruder motor has problems pulling it from the spool, it will result in a missing part on the layer being laid.
3. Store your filament in a plastic bag with some dissecant or rice in it. Damp filament makes little bubbles of steam that explode resulting in objects with a sandpaper texture. The higher the resolution, the rougher it will feel. Look with a magnifying glass and you will see them specially in black filament.